Interferon γ Attenuates Insulin Signaling, Lipid Storage, and Differentiation in Human Adipocytes via Activation of the JAK/STAT Pathway

Recent reports demonstrate T-cell infiltration of adipose tissue in early obesity. We hypothesized that interferon (IFN) γ, a major T-cell inflammatory cytokine, would attenuate human adipocyte functions and sought to establish signaling mechanisms. Differentiated human adipocytes were treated with...

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Detalhes bibliográficos
Main Authors: McGillicuddy, Fiona C., Chiquoine, Elise H., Hinkle, Christine C., Kim, Roy J., Shah, Rachana, Roche, Helen M., Smyth, Emer M., Reilly, Muredach P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Metabolism and Bioenergetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797265/
https://ncbi.nlm.nih.gov/pubmed/19776010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.061655
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