Structural Snapshots of Heparin Depolymerization by Heparin Lyase I

Heparin lyase I (heparinase I) specifically depolymerizes heparin, cleaving the glycosidic linkage next to iduronic acid. Here, we show the crystal structures of heparinase I from Bacteroides thetaiotaomicron at various stages of the reaction with heparin oligosaccharides before and just after cleav...

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Detalhes bibliográficos
Main Authors: Han, Young-Hyun, Garron, Marie-Line, Kim, Hye-Yeon, Kim, Wan-Seok, Zhang, Zhenqing, Ryu, Kyeong-Seok, Shaya, David, Xiao, Zhongping, Cheong, Chaejoon, Kim, Yeong Shik, Linhardt, Robert J., Jeon, Young Ho, Cygler, Miroslaw
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2797172/
https://ncbi.nlm.nih.gov/pubmed/19801541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.025338
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