Crystal Structure of an RluF–RNA Complex: A Base-Pair Rearrangement Is the Key to Selectivity of RluF for U2604 of the Ribosome

Escherichia coli pseudouridine synthase RluF is dedicated to modifying U2604 in a stem–loop of 23S RNA, while a homologue, RluB, modifies the adjacent base, U2605. Both uridines are in the same RNA stem, separated by ~4 Å. The 3.0 Å X-ray crystal structure of RluF bound to the isolated stem–loop, in...

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Hauptverfasser: Alian, Akram, DeGiovanni, Andrew, Griner, Sarah L., Finer-Moore, Janet S., Stroud, Robert M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796871/
https://ncbi.nlm.nih.gov/pubmed/19298824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2009.03.029
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