Avoiding the high Bonferroni penalty in genome-wide association studies

A major challenge in genome-wide association studies (GWASs) is to derive the multiple testing threshold when hypothesis tests are conducted using a large number of single nucleotide polymorphisms. Permutation tests are considered the gold standard in multiple testing adjustment in genetic associati...

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Bibliographic Details
Main Authors: Gao, Xiaoyi, Becker, Lewis C., Becker, Diane M., Starmer, Joshua D., Province, Michael A.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796708/
https://ncbi.nlm.nih.gov/pubmed/19434714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/gepi.20430
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