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Molecular cloning of amyloid cDNA derived from mRNA of the Alzheimer disease brain: coding and noncoding regions of the fetal precursor mRNA are expressed in the cortex.

To gain insight into factors associated with the excessive accumulation of beta-amyloid in the Alzheimer disease (AD) brain, the present studies were initiated to distinguish between a unique primary structure of the AD-specific amyloid precursor mRNA vis a vis other determinants that may affect amy...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Zain, S B, Salim, M, Chou, W G, Sajdel-Sulkowska, E M, Majocha, R E, Marotta, C A
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1988
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC279670/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2893379/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.85.3.929
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