HIV Nef is secreted in exosomes and triggers apoptosis in bystander CD4(+) T cells

The HIV accessory protein Nef is one of the earliest and most abundantly expressed viral proteins. It is also found in the serum of infected individuals (Caby et. al, 2005). Extracellular Nef protein has deleterious effects on CD4(+) T cells (James et. al, 2004), the primary targets of HIV, and can...

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Main Authors: Lenassi, Metka, Cagney, Gerard, Liao, Maofu, Vaupotič, Tomaž, Bartholomeeusen, Koen, Cheng, Yifan, Krogan, Nevan J., Plemenitaš, Ana, Peterlin, B. Matija
格式: Artigo
語言:Inglês
出版: 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796297/
https://ncbi.nlm.nih.gov/pubmed/19912576
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-0854.2009.01006.x
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