Platelet polyphosphates are proinflammatory and procoagulant mediators in vivo

Platelets play a central role in thrombosis, hemostasis, and inflammation. We show that activated platelets release inorganic polyphosphate (polyP), a polymer of 60-100 phosphate residues that directly bound to and activated the plasma protease factor XII. PolyP-driven factor XII-activation triggere...

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Detalhes bibliográficos
Main Authors: Müller, Felicitas, Mutch, Nicola J., Schenk, Wolfdieter A., Smith, Stephanie A., Esterl, Lucie, Spronk, Henri M., Schmidbauer, Stefan, Gahl, William A., Morrissey, James H., Renné, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796262/
https://ncbi.nlm.nih.gov/pubmed/20005807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2009.11.001
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