Induction of Ovarian Leiomyosarcomas in Mice by Conditional Inactivation of Brca1 and p53

BACKGROUND: Approximately one out of every ten cases of epithelial ovarian cancer (EOC) is inherited. The majority of inherited cases of EOC result from mutations in the breast cancer associated gene 1 (BRCA1). In addition to mutation of BRCA1, mutation of the p53 gene is often found in patients wit...

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Detalhes bibliográficos
Main Authors: Quinn, Bridget A., Brake, Tiffany, Hua, Xiang, Baxter-Jones, Kimberly, Litwin, Samuel, Ellenson, Lora Hedrick, Connolly, Denise C.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796165/
https://ncbi.nlm.nih.gov/pubmed/20046879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008404
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