Vitamin D inhibits growth of human airway smooth muscle cells through growth factor-induced phosphorylation of retinoblastoma protein and checkpoint kinase 1

BACKGROUND AND PURPOSE: Airway remodelling in asthma is manifested, in part, as increased airway smooth muscle (ASM) mass, reflecting myocyte proliferation. We hypothesized that calcitriol, a secosteroidal vitamin D receptor (VDR) modulator, would inhibit growth factor-induced myocyte proliferation....

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Autores principales: Damera, G, Fogle, HW, Lim, P, Goncharova, EA, Zhao, H, Banerjee, A, Tliba, O, Krymskaya, VP, Panettieri, RA
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Ltd 2009
Materias:
Research Paper with Commentary
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2795210/
https://ncbi.nlm.nih.gov/pubmed/19814732
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2009.00428.x
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