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The total synthesis of 2-O-arachidonoyl-1-O-stearoyl-sn-glycero-3-phosphocholine-1,3,1′-(13)C(3) and -2,1′-(13)C(2) by a novel chemoenzymatic method

2-O-Arachidonoyl-1-O-stearoyl-sn-glycero-3-phosphocholine was synthesized with carbon-13 enrichment of the three glycerol carbons and the carbonyl of the stearoyl group. Phospholipase A(2) was utilized to give optically pure lyso-PC, and only 3% acyl migration occurred during reacylation with arachi...

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Detalhes bibliográficos
Autor principal: Duclos, Richard I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2795044/
https://ncbi.nlm.nih.gov/pubmed/19682980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chemphyslip.2009.08.001
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