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Suppression of alcohol preference by naltrexone in the rhesus macaque: A critical role of genetic variation at the μ-opioid receptor gene (OPRM1) locus
BACKGROUND: The role of a non-synonymous A118G polymorphism of the human mu-opioid receptor gene (OPRM1) for alcohol reward and therapeutic efficacy of naltrexone remains controversial. A functionally equivalent OPRM1 C77G polymorphism in rhesus macaques allows this to be addressed under controlled...
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| Auteurs principaux: | , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2794913/ https://ncbi.nlm.nih.gov/pubmed/19748082 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2009.07.026 |
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