A Turn-like Structure “KKPE” Segment Mediates the Specific Binding of Viral Protein A27 to Heparin and Heparan Sulfate on Cell Surfaces

Vaccinia viral envelope protein A27 (110 amino acids) specifically interacts with heparin (HP) or heparan sulfate (HS) proteoglycans for cell surface attachment. To examine the binding mechanism, a truncated soluble form of A27 (sA27-aa; residues 21–84 of A27) with Cys(71) and Cys(72) mutated to Ala...

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Main Authors: Shih, Ping-Chen, Yang, Min-Shiang, Lin, Su-Ching, Ho, Yu, Hsiao, Jye-Chian, Wang, Da-Rong, Yu, Steve S.-F., Chang, Wen, Tzou, Der-Lii M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794769/
https://ncbi.nlm.nih.gov/pubmed/19858217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.037267
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