PPARγ activation in adipocytes is sufficient for systemic insulin sensitization

Although peroxisome proliferator-activated receptor gamma (PPARγ) agonists such as thiazolidinediones (TZDs) are widely used to treat type 2 diabetes, how its activation in individual tissues contributes to TZD's therapeutic action remains controversial. As TZDs are known to have receptor-indep...

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Bibliographic Details
Main Authors: Sugii, Shigeki, Olson, Peter, Sears, Dorothy D., Saberi, Maziyar, Atkins, Annette R., Barish, Grant D., Hong, Suk-Hyun, Castro, Glenda L., Yin, Yun-Qiang, Nelson, Michael C., Hsiao, Gene, Greaves, David R., Downes, Michael, Yu, Ruth T., Olefsky, Jerrold M., Evans, Ronald M.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2009
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794650/
https://ncbi.nlm.nih.gov/pubmed/20018750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0912487106
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