Activation of Wnt/β-Catenin Signaling Increases Insulin Sensitivity through a Reciprocal Regulation of Wnt10b and SREBP-1c in Skeletal Muscle Cells

BACKGROUND: Intramyocellular lipid accumulation is strongly related to insulin resistance in humans, and we have shown that high glucose concentration induced de novo lipogenesis and insulin resistance in murin muscle cells. Alterations in Wnt signaling impact the balance between myogenic and adipog...

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Hoofdauteurs: Abiola, Mounira, Favier, Maryline, Christodoulou-Vafeiadou, Eleni, Pichard, Anne-Lise, Martelly, Isabelle, Guillet-Deniau, Isabelle
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2009
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794543/
https://ncbi.nlm.nih.gov/pubmed/20041157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0008509
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