Systems toxicology study of doxorubicin on rats using ultra performance liquid chromatography coupled with mass spectrometry based metabolomics

A metabolomics-based systems toxicology approach was used to profile the urinary metabolites for the toxicity related processes and pathogenesis induced by doxorubicin (DOX) to rats. Endogenous metabolite profiles were obtained with ultra performance liquid chromatography-mass spectrometry (UPLC-MS)...

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Detalhes bibliográficos
Main Authors: Wang, Jiangshan, Reijmers, Theo, Chen, Lijuan, Van Der Heijden, Rob, Wang, Mei, Peng, Shuangqing, Hankemeier, Thomas, Xu, Guowang, Van Der Greef, Jan
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2009
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794350/
https://ncbi.nlm.nih.gov/pubmed/20046867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11306-009-0165-3
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