The Role of Hypoxia in 2-Butoxyethanol–Induced Hemangiosarcoma

To understand the molecular mechanisms underlying compound-induced hemangiosarcomas in mice, and therefore, their human relevance, a systems biology approach was undertaken using transcriptomics and Causal Network Modeling from mice treated with 2-butoxyethanol (2-BE). 2-BE is a hemolytic agent that...

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Main Authors: Laifenfeld, Daphna, Gilchrist, Annalyn, Drubin, David, Jorge, Milena, Eddy, Sean F., Frushour, Brian P., Ladd, Bill, Obert, Leslie A., Gosink, Mark M., Cook, Jon C., Criswell, Kay, Somps, Christopher J., Koza-Taylor, Petra, Elliston, Keith O., Lawton, Michael P.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2010
Assuntos:
Systems Toxicology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2794330/
https://ncbi.nlm.nih.gov/pubmed/19812364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfp213
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