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A reciprocal interdependence between Nck and phosphatidylinositol 4,5 bisphosphate promotes localized N-WASp-mediated actin polymerization in living cells
Modulation of actin dynamics through the N-WASp/Arp2/3 pathway is important in cell locomotion, membrane trafficking, and pathogen infection. Here, we demonstrate that Nck is essential for actin remodeling stimulated by phosphatidylinositol 4,5 bisphosphate (PI(4,5)P(2)), and conversely that PI(4,5)...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2793683/ https://ncbi.nlm.nih.gov/pubmed/19917259 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.10.025 |
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