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Total HLA class I loss in a sarcomatoid renal carcinoma cell line caused by the coexistence of distinct mutations in the two encoding β(2)-microglobulin genes

In renal cell carcinoma (RCC), HLA class I downregulation has been found in about 40% of the lesions examined. Since only scanty information is available about the molecular basis of these defects, we have investigated the mechanism(s) underlying HLA class I antigen down-regulation or loss in six RC...

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Detalhes bibliográficos
Main Authors: Hsieh, Chin-Hsuan, Hsu, Ya-Jan, Chang, Chien-Chung, Liu, Hsin-Chun, Chuang, Kun-Lung, Chuang, Cheng-Keng, Pang, See-Tong, Hasumi, Kenichiro, Ferrone, Soldano, Liao, Shuen-Kuei
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2793116/
https://ncbi.nlm.nih.gov/pubmed/18704411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-008-0565-7
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