Long-term Fenretinide treatment prevents high-fat diet-induced obesity, insulin resistance, and hepatic steatosis

The synthetic retinoid Fenretinide (FEN) increases insulin sensitivity in obese rodents and is in early clinical trials for treatment of insulin resistance in obese humans with hepatic steatosis (46). We aimed to determine the physiological mechanisms for the insulin-sensitizing effects of FEN. Wild...

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Bibliographic Details
Main Authors: Preitner, Frederic, Mody, Nimesh, Graham, Timothy E., Peroni, Odile D., Kahn, Barbara B.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2009
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2793052/
https://ncbi.nlm.nih.gov/pubmed/19826103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00362.2009
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