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A Study on Improvement of Solubility of Rofecoxib and its effect on Permeation of Drug from Topical Formulations
Rofecoxib, a practically insoluble cox-2 selective nonsteroidal antiinflammatory agent was subjected to improvement in solubility by preparing its binary mixtures with β cyclodextrin using various methods such as physical mixing, co-grinding, kneading with aqueous methanol and co-evaporation from me...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Medknow Publications
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2792560/ https://ncbi.nlm.nih.gov/pubmed/20046772 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/0250-474X.44595 |
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