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Differential proteomics analysis of the surface heterogeneity of dextran iron oxide nanoparticles and the implications for their in vivo clearance

In order to understand the role of plasma proteins in the rapid liver clearance of dextran-coated superparamagnetic iron oxide (SPIO) in vivo, we analyzed the full repertoire of SPIO-binding blood proteins using novel two-dimensional differential mass spectrometry approach. The identified proteins s...

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Autors principals: Simberg, Dmitri, Park, Ji-Ho, Karmali, Priya P., Zhang, Wan-Ming, Merkulov, Sergei, McCrae, Keith, Bhatia, Sangeeta, Sailor, Michael, Ruoslahti, Erkki
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2792080/
https://ncbi.nlm.nih.gov/pubmed/19394687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2009.03.056
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