Integrating Structure, Bioinformatics, and Enzymology to Discover Function: BioH, A NEW CARBOXYLESTERASE FROM ESCHERICHIA COLI

Structural proteomics projects are generating three-dimensional structures of novel, uncharacterized proteins at an increasing rate. However, structure alone is often insufficient to deduce the specific biochemical function of a protein. Here we determined the function for a protein using a strategy...

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Detalhes bibliográficos
Main Authors: Sanishvili, Ruslan, Yakunin, Alexander F., Laskowski, Roman A., Skarina, Tatiana, Evdokimova, Elena, Doherty-Kirby, Amanda, Lajoie, Gilles A., Thornton, Janet M., Arrowsmith, Cheryl H., Savchenko, Alexei, Joachimiak, Andrzej, Edwards, Aled M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2792009/
https://ncbi.nlm.nih.gov/pubmed/12732651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M303867200
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