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The stabilisation of purified, reconstituted P-glycoprotein by freeze drying with disaccharides
The drug efflux pump P-glycoprotein (P-gp) (ABCB1) confers multidrug resistance, a major cause of failure in the chemotherapy of tumours, exacerbated by a shortage of potent and selective inhibitors. A high throughput assay using purified P-gp to screen and characterise potential inhibitors would gr...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2791872/ https://ncbi.nlm.nih.gov/pubmed/18983838 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cryobiol.2008.10.125 |
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