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Capturing Dopaminergic Modulation and Bimodal Membrane Behaviour of Striatal Medium Spiny Neurons in Accurate, Reduced Models

Loss of dopamine from the striatum can cause both profound motor deficits, as in Parkinson's disease, and disrupt learning. Yet the effect of dopamine on striatal neurons remains a complex and controversial topic, and is in need of a comprehensive framework. We extend a reduced model of the str...

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Hlavní autoři: Humphries, Mark D., Lepora, Nathan, Wood, Ric, Gurney, Kevin
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Research Foundation 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2791037/
https://ncbi.nlm.nih.gov/pubmed/20011223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/neuro.10.026.2009
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