Tumor Necrosis Factor α Represses Bone Morphogenetic Protein (BMP) Signaling by Interfering with the DNA Binding of Smads through the Activation of NF-κB

Bone morphogenetic proteins (BMPs) induce not only bone formation in vivo but also osteoblast differentiation of mesenchymal cells in vitro. Tumor necrosis factor α (TNFα) inhibits both osteoblast differentiation and bone formation induced by BMPs. However, the molecular mechanisms of these inhibiti...

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Detalhes bibliográficos
Main Authors: Yamazaki, Masato, Fukushima, Hidefumi, Shin, Masashi, Katagiri, Takenobu, Doi, Takahiro, Takahashi, Tetsu, Jimi, Eijiro
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2791026/
https://ncbi.nlm.nih.gov/pubmed/19854828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.070540
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