Critical role for hypothalamic mTOR activity in energy balance

The mammalian target of Rapamycin (mTOR) promotes anabolic cellular processes in response to growth factors and metabolic cues. The TSC1 and TSC2 tumor suppressors are major upstream inhibitory regulators of mTOR signaling. Mice with Rip2/Cre-mediated deletion of Tsc1 (Rip-Tsc1cKO mice) developed hy...

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Detalhes bibliográficos
Main Authors: Mori, Hiroyuki, Inoki, Ken, Münzberg, Heike, Opland, Darren, Faouzi, Miro, Villanueva, Eneida C., Ikenoue, Tsuneo, Kwiatkowski, David, MacDougald, Ormond A, Myers, Martin G., Guan, Kun-Liang
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790375/
https://ncbi.nlm.nih.gov/pubmed/19356717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2009.03.005
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