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Tradeoff Between Stability and Multispecificity in the Design of Promiscuous Proteins
Natural proteins often partake in several highly specific protein-protein interactions. They are thus subject to multiple opposing forces during evolutionary selection. To be functional, such multispecific proteins need to be stable in complex with each interaction partner, and, at the same time, to...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2790338/ https://ncbi.nlm.nih.gov/pubmed/20041208 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1000627 |
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