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The PPARα agonist, fenofibrate, preserves hippocampal neurogenesis and inhibits microglial activation following whole-brain irradiation
PURPOSE: Whole-brain irradiation (WBI) leads to cognitive impairment months to years after radiation. Numerous studies suggest that decreased hippocampal neurogenesis and microglial activation are involved in the pathogenesis of WBI-induced brain injury. The goal of this study was to investigate whe...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2789462/ https://ncbi.nlm.nih.gov/pubmed/19801103 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2009.06.059 |
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