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Simulations of anion transport through OprP reveal the molecular basis for high affinity and selectivity for phosphate

The outer membrane protein OprP from Pseudomonas aeruginosa forms a phosphate selective pore. To understand the mechanism of phosphate permeation and selectivity, we used three simulation techniques [equilibrium molecular dynamics simulations, steered molecular dynamics, and calculation of a potenti...

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Detalhes bibliográficos
Main Authors: Pongprayoon, Prapasiri, Beckstein, Oliver, Wee, Chze Ling, Sansom, Mark S. P.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2789165/
https://ncbi.nlm.nih.gov/pubmed/19966228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0907315106
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