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The Terminal Region of β-Catenin Promotes Stability by Shielding the Armadillo Repeats from the Axin-scaffold Destruction Complex
Post-translational stabilization of β-catenin is a key step in Wnt signaling, but the features of β-catenin required for stabilization are incompletely understood. We show that forms of β-catenin lacking the unstructured C-terminal domain (CTD) show faster turnover than full-length or minimally trun...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2788874/ https://ncbi.nlm.nih.gov/pubmed/19706613 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.045039 |
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