The Terminal Region of β-Catenin Promotes Stability by Shielding the Armadillo Repeats from the Axin-scaffold Destruction Complex

Post-translational stabilization of β-catenin is a key step in Wnt signaling, but the features of β-catenin required for stabilization are incompletely understood. We show that forms of β-catenin lacking the unstructured C-terminal domain (CTD) show faster turnover than full-length or minimally trun...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Mo, Rigen, Chew, Teng-Leong, Maher, Meghan T., Bellipanni, Gianfranco, Weinberg, Eric S., Gottardi, Cara J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2009
Gaiak:
Mechanisms of Signal Transduction
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788874/
https://ncbi.nlm.nih.gov/pubmed/19706613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.045039
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