Design and Synthesis of Imidazopyrimidine Derivatives as Potent iNOS Dimerization Inhibitors

A series of imidazopyrimidine derivatives with the general formula I was synthesized and identified as potent inhibitors of iNOS dimer formation, a prerequisite for proper functioning of the enzyme. Stille and Negishi coupling reactions were used as key steps to form the carbon-carbon bond connectin...

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Hlavní autoři: Chu, Guo-Hua, Le Bourdonnec, Bertrand, Gu, Minghua, Ajello, Christopher W, Leister, Lara K, Sellitto, Ian, Cassel, Joel A, Tuthill, Paul A, O’ Hare, Heather, DeHaven, Robert N, Dolle, Roland E
Médium: Artigo
Jazyk:Inglês
Vydáno: Bentham Open 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788740/
https://ncbi.nlm.nih.gov/pubmed/19966921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/1874104500903010008
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