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Use of nfsB, encoding nitroreductase, as a reporter gene to determine the mutational spectrum of spontaneous mutations in Neisseria gonorrhoeae

BACKGROUND: Organisms that are sensitive to nitrofurantoin express a nitroreductase. Since bacterial resistance to this compound results primarily from mutations in the gene encoding nitroreductase, the resulting loss of function of nitroreductase results in a selectable phenotype; resistance to nit...

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Bibliografske podrobnosti
Main Authors: Stein, Daniel C, Carrizosa, Esteban, Dunham, Stephen
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788575/
https://ncbi.nlm.nih.gov/pubmed/19930647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2180-9-239
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