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The Human Neonatal B Cell Response to Respiratory Syncytial Virus Uses a Biased Antibody Variable Gene Repertoire that Lacks Somatic Mutations
The human Ab repertoire exhibits restrictions during fetal life characterized by biases of variable gene segment usage and lack of junctional diversity. We tested the hypotheses that Ab repertoire restriction persists in the early postnatal period and contributes to the observed poor quality of spec...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2788105/ https://ncbi.nlm.nih.gov/pubmed/19804909 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molimm.2009.08.024 |
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