A case of dementia with PRNP D178Ncis-129M and no insomnia

OBJECTIVE: To describe a dementia case clinically diagnosed as Alzheimer’s disease with a PRNP genotype usually associated with Familial Fatal insomnia. METHODS: PCR amplification and subsequent direct sequencing of PGRN, MAPT, PSEN1, PSEN2, APP and PRNP genes. RESULTS: A point mutation (D178N) was...

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Bibliografiska uppgifter
Huvudupphovsmän: Guerreiro, Rita J., Vaskov, Tina, Crews, Cynthia, Singleton, Andrew, Hardy, John
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787867/
https://ncbi.nlm.nih.gov/pubmed/19571725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/WAD.0b013e3181ae3a76
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