Epitope mapping immunodominant regions of the PilA protein of nontypeable Haemophilus influenzae (NTHI) to facilitate the design of two novel chimeric vaccine candidates

We designed and tested three PilA-derived vaccine candidates in a chinchilla model of ascending nontypeable Haemophilus influenzae (NTHI)-induced otitis media (OM). Delivery of antiserum directed against each immunogen conferred varying degrees of protection. Presentation of a B-cell epitope derived...

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Autori principali: Novotny, Laura A., Adams, Leanne D., Kang, D. Richard, Wiet, Gregory J., Cai, Xueya, Sethi, Sanjay, Murphy, Timothy F., Bakaletz, Lauren O.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787809/
https://ncbi.nlm.nih.gov/pubmed/19699813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2009.08.017
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