Gene Related to Anergy in Lymphocytes (GRAIL) Expression in CD4+ T Cells Impairs Actin Cytoskeletal Organization during T Cell/Antigen-presenting Cell Interactions

GRAIL (gene related to anergy in lymphocytes), is an E3 ubiquitin ligase with increased expression in anergic CD4+ T cells. The expression of GRAIL has been shown to be both necessary and sufficient for the induction of T cell (T) anergy. To date, several subsets of anergic T cells have demonstrated...

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Detalhes bibliográficos
Main Authors: Schartner, Jill M., Simonson, William T., Wernimont, Sarah A., Nettenstrom, Lauren M., Huttenlocher, Anna, Seroogy, Christine M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Molecular Basis of Cell and Developmental Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787330/
https://ncbi.nlm.nih.gov/pubmed/19833735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.024497
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