Expression of the Human Cytomegalovirus UL97 Gene in a Chimeric Guinea Pig Cytomegalovirus (GPCMV) Results in Viable Virus with Increased Susceptibility to Ganciclovir and Maribavir

In lieu of a licensed vaccine, antivirals are being considered as an intervention to prevent congenital human cytomegalovirus (HCMV) infection. Ideally, antiviral therapies should undergo pre-clinical evaluation in an animal model prior to human use. Guinea pig cytomegalovirus (GPCMV) is the only sm...

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Hoofdauteurs: McGregor, Alistair, Choi, K. Yeon, Cui, Xiaohong, McVoy, Michael A., Schleiss, Mark R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2008
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787096/
https://ncbi.nlm.nih.gov/pubmed/18325607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2008.01.008
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