LPS stimulates platelet secretion and potentiates platelet aggregation via TLR4/MyD88 and the cGMP-dependent protein kinase pathway

Bacterial lipopolysaccharide (LPS) induces rapid thrombocytopenia, hypotension and sepsis. Although growing evidence suggests that platelet activation plays a critical role in LPS-induced thrombocytopenia and tissue damage, the mechanism of LPS-mediated platelet activation is unclear. Here we show t...

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Main Authors: Zhang, Guoying, Han, Jingyan, Welch, Emily J., Ye, Richard D., Voyno-Yasenetskaya, Tatyana A., Malik, Asrar B., Du, Xiaoping, Li, Zhenyu
格式: Artigo
語言:Inglês
出版: 2009
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787095/
https://ncbi.nlm.nih.gov/pubmed/19494325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0802884
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