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Transcriptional Downregulation of p27KIP1 through Regulation of E2F Function during LMP1-Mediated Transformation

LMP1 induces the phenotypic transformation of fibroblasts and affects regulators of the cell cycle during this process. LMP1 decreases expression of the cyclin-dependent kinase inhibitor p27 and increases the levels and phosphorylation of cyclin-dependent kinase 2 and the retinoblastoma protein. In...

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Bibliografische gegevens
Hoofdauteurs: Everly, David N., Mainou, Bernardo A., Raab-Traub, Nancy
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology (ASM) 2009
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786828/
https://ncbi.nlm.nih.gov/pubmed/19828622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01422-09
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