The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells

The polycomb group protein B lymphoma Mo-MLV insertion region 1 homolog (Bmi-1) is dysregulated in various cancers, and its upregulation strongly correlates with an invasive phenotype and poor prognosis in patients with nasopharyngeal carcinomas. However, the underlying mechanism of Bmi-1–mediated i...

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Detalhes bibliográficos
Main Authors: Song, Li-Bing, Li, Jun, Liao, Wen-Ting, Feng, Yan, Yu, Chun-Ping, Hu, Li-Juan, Kong, Qing-Li, Xu, Li-Hua, Zhang, Xing, Liu, Wan-Li, Li, Man-Zhi, Zhang, Ling, Kang, Tie-Bang, Fu, Li-Wu, Huang, Wen-Lin, Xia, Yun-Fei, Tsao, Sai Wah, Li, Mengfeng, Band, Vimla, Band, Hamid, Shi, Qing-Hua, Zeng, Yi-Xin, Zeng, Mu-Sheng
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786794/
https://ncbi.nlm.nih.gov/pubmed/19884659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI39374
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