Pyrosequencing for Rapid Detection of Mycobacterium tuberculosis Resistance to Rifampin, Isoniazid, and Fluoroquinolones

After isoniazid and rifampin (rifampicin), the next pivotal drug class in Mycobacterium tuberculosis treatment is the fluoroquinolone class. Mutations in resistance-determining regions (RDR) of the rpoB, katG, and gyrA genes occur with frequencies of 97%, 50%, and 85% among M. tuberculosis isolates...

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Detalhes bibliográficos
Main Authors: Bravo, Lulette Tricia C., Tuohy, Marion J., Ang, Concepcion, Destura, Raul V., Mendoza, Myrna, Procop, Gary W., Gordon, Steven M., Hall, Geraldine S., Shrestha, Nabin K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Mycobacteriology and Aerobic Actinomycetes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786679/
https://ncbi.nlm.nih.gov/pubmed/19846642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.01229-09
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