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A Heterologous Helper T-Cell Epitope Enhances the Immunogenicity of a Multiple-Antigenic-Peptide Vaccine Targeting the Cryptic Loop-Neutralizing Determinant of Bacillus anthracis Protective Antigen

We previously showed that a multiple antigenic peptide (MAP) displaying amino acids (aa) 305 to 319 from the 2β2-2β3 loop of protective antigen (PA) can elicit high-titered antibody that neutralizes lethal toxin (LeTx) in vitro and that this loop-neutralizing determinant (LND) specificity is absent...

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Detalles Bibliográficos
Main Authors: Oscherwitz, Jon, Yu, Fen, Cease, Kemp B.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2009
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786483/
https://ncbi.nlm.nih.gov/pubmed/19805525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00899-09
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