ST-246 Inhibits In Vivo Poxvirus Dissemination, Virus Shedding, and Systemic Disease Manifestation

Orthopoxvirus infections, such as smallpox, can lead to severe systemic disease and result in considerable morbidity and mortality in immunologically naïve individuals. Treatment with ST-246, a small-molecule inhibitor of virus egress, has been shown to provide protection against severe disease and...

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Main Authors: Berhanu, Aklile, King, David S., Mosier, Stacie, Jordan, Robert, Jones, Kevin F., Hruby, Dennis E., Grosenbach, Douglas W.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2009
Fag:
Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786374/
https://ncbi.nlm.nih.gov/pubmed/19752270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00678-09
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