Unbound Cephalothin Pharmacokinetics in Adult Burn Patients Are Related to the Elapsed Time after Injury

Cephalothin (cefalotin) pharmacokinetics were evaluated for nine severely burned patients (42% ± 9% mean burn areas) and five healthy volunteers by using non-plasma-protein-bound concentration-time profiles. Burn patients gave increased mean residence times (36%) and reduced total clearances (25%)....

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Autori principali: Dalley, Andrew J., Deans, Renae, Lipman, Jeffrey, Venkatesh, Bala, Rudd, Michael, Roberts, Michael S., Cross, Sheree E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2009
Soggetti:
Pharmacology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786355/
https://ncbi.nlm.nih.gov/pubmed/19752272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01600-08
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