Structural Basis for Enzymatic Evolution from a Dedicated ADP-ribosyl Cyclase to a Multifunctional NAD Hydrolase

Cyclic ADP-ribose (cADPR) is a universal calcium messenger molecule that regulates many physiological processes. The production and degradation of cADPR are catalyzed by a family of related enzymes, including the ADP-ribosyl cyclase from Aplysia california (ADPRAC) and CD38 from human. Although ADPR...

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Bibliographic Details
Main Authors: Liu, Qun, Graeff, Richard, Kriksunov, Irina A., Jiang, Hong, Zhang, Bo, Oppenheimer, Norman, Lin, Hening, Potter, Barry V. L., Lee, Hon Cheung, Hao, Quan
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785692/
https://ncbi.nlm.nih.gov/pubmed/19640846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.031005
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