Mechanism of Cyclizing NAD to Cyclic ADP-ribose by ADP-ribosyl Cyclase and CD38

Mammalian CD38 and its Aplysia homolog, ADP-ribosyl cyclase (cyclase), are two prominent enzymes that catalyze the synthesis and hydrolysis of cyclic ADP-ribose (cADPR), a Ca(2+) messenger molecule responsible for regulating a wide range of cellular functions. Although both use NAD as a substrate, t...

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Bibliographic Details
Main Authors: Graeff, Richard, Liu, Qun, Kriksunov, Irina A., Kotaka, Masayo, Oppenheimer, Norman, Hao, Quan, Lee, Hon Cheung
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Enzyme Catalysis and Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785691/
https://ncbi.nlm.nih.gov/pubmed/19640843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.030965
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