Biological Activity of Ectodysplasin A Is Conditioned by Its Collagen and Heparan Sulfate Proteoglycan-binding Domains

Mutations in the TNF family ligand EDA1 cause X-linked hypohidrotic ectodermal dysplasia (XLHED), a condition characterized by defective development of skin appendages. The EDA1 protein displays a proteolytic processing site responsible for its conversion to a soluble form, a collagen domain, and a...

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Detalhes bibliográficos
Main Authors: Swee, Lee Kim, Ingold-Salamin, Karine, Tardivel, Aubry, Willen, Laure, Gaide, Olivier, Favre, Manuel, Demotz, Stéphane, Mikkola, Marja, Schneider, Pascal
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785685/
https://ncbi.nlm.nih.gov/pubmed/19657145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.042259
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