Transglutaminase-mediated Intramolecular Cross-linking of Membrane-bound α-Synuclein Promotes Amyloid Formation in Lewy Bodies

The α-synuclein immunopositive and chaotrope-insoluble material from human brains with Lewy body pathology was analyzed by mass spectrometry. From the proteinase K-cleavable peripheral fraction of Lewy bodies, which was densely cross-linked by γ-glutamyl-ϵ-lysine bonds between HspB1 and ubiquitin in...

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Bibliografiske detaljer
Main Authors: Nemes, Zoltán, Petrovski, Goran, Aerts, Maarten, Sergeant, Kjell, Devreese, Bart, Fésüs, László
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Protein Synthesis, Post-Translational Modification, and Degradation
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785653/
https://ncbi.nlm.nih.gov/pubmed/19651786
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.033969
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