Regulation of Expression of the Rat Orthologue of Mouse Double Minute 2 (MDM2) by H(2)O(2)-induced Oxidative Stress in Neonatal Rat Cardiac Myocytes

The Mdm2 ubiquitin ligase is an important regulator of p53 abundance and p53-dependent apoptosis. Mdm2 expression is frequently regulated by a p53 Mdm2 autoregulatory loop whereby p53 stimulates Mdm2 expression and hence its own degradation. Although extensively studied in cell lines, relatively lit...

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Main Authors: Pikkarainen, Sampsa, Kennedy, Robert A., Marshall, Andrew K., Tham, El Li, Lay, Kenneth, Kriz, Thomas A., Handa, Balvinder S., Clerk, Angela, Sugden, Peter H.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2009
Teme:
Transcription, Chromatin, and Epigenetics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785647/
https://ncbi.nlm.nih.gov/pubmed/19638633
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.037887
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