Elimination of the CDP-ethanolamine Pathway Disrupts Hepatic Lipid Homeostasis

Phosphoethanolamine cytidylyltransferase (ECT) catalyzes the rate-controlling step in a major pathway for the synthesis of phosphatidylethanolamine (PtdEtn). Hepatocyte-specific deletion of the ECT gene in mice resulted in normal appearing animals without overt signs of liver injury or inflammation....

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Hlavní autoři: Leonardi, Roberta, Frank, Matthew W., Jackson, Pamela D., Rock, Charles O., Jackowski, Suzanne
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2009
Témata:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785637/
https://ncbi.nlm.nih.gov/pubmed/19666474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.031336
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